50-03-3 MSDS - Hydrocortisone acetate
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Hydrocortisone acetate

Identification
Name Hydrocortisone acetate
CAS Registry Number 50-03-3
Synonyms (11beta)-21-(Acetoxy)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione;11,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl acetate;11-beta,17-alpha-dihydroxy-21-acetoxypregesterone;11beta17alpha-Dihydroxy-21-acetoxypregesterone;17-alpha-hydrocorticosterone21-acetate;17alpha-Hydrocorticosterone-21-acetate;17-dihydroxy-20-dion(11-beta)-pregn-4-ene-21-(acetoxy)-11;17-dihydroxy-20-dion(11beta)-pregn-4-ene-21-(acetyloxy)-11
Molecular Structure Hydrocortisone acetate   50-03-3
Molecular Formula C23H32O6
Molecular Weight 404.5
mp: 223 ℃ (dec.)(lit.)
Hazard Codes: Details
Risk Statements: 63
Safety Statements: 36/37
Supplier
Lightchem Inc
Supply Precious metal catalyst
OLED Materials etc.
www.lightchem.com
 
Wiki & MSDS
50-03-3.pdf
Hydrocortisone
Cortisol2.svg
Cortisol-3D-balls.png
Clinical data
Trade names Cortef, Solu-Cortef, others[1]
AHFS/Drugs.com Monograph
MedlinePlus a682206
License data
  • US FDA: Hydrocortisone
Pregnancy
category
  • AU: A
  • US: C (Risk not ruled out)
Routes of
administration
By mouth (tablets), intravenous, topical, rectal
ATC code
  • A01AC03 (WHO) A07EA02 (WHO) C05AA01 (WHO) D07AA02 (WHO) H02AB09 (WHO) S01BA02 (WHO) S02BA01 (WHO)
Legal status
Legal status
  • AU: S3 (Pharmacist only)
  • UK: POM (Prescription only)
  • US: OTC for topical administration; Rx-only for oral tablets, rectal use and intravenous therapy
Identifiers
CAS Number
  • 50-23-7 YesY
PubChem CID
  • 5754
DrugBank
  • DB00741 N
ChemSpider
  • 5551 YesY
UNII
  • WI4X0X7BPJ
KEGG
  • D00088 YesY
ChEBI
  • CHEBI:17650 YesY
ChEMBL
  • CHEMBL389621 YesY
Chemical and physical data
Formula C21H30O5
Molar mass 362.460 g/mol
3D model (Jmol)
  • Interactive image
 NYesY (what is this?)  (verify)

Hydrocortisone, sold under the brandname Cortef among others, is the name for the hormone cortisol when supplied as a medication.[2] Uses includes conditions such as adrenocortical insufficiency, adrenogenital syndrome, high blood calcium, thyroiditis, rheumatoid arthritis, dermatitis, asthma, and COPD.[1] It is the treatment of choice for adrenocortical insufficiency.[3] It can be given by mouth or by injection.[1] After long-term use, if stopped this should be done slowly.[1]

Side effects may include mood changes, increased risk of infection, and swelling.[1] With long-term use common side effects include osteoporosis, upset stomach, physical weakness, easy bruising, and yeast infections.[1] While used, it is unclear if it is safe during pregnancy.[4] It works as an antiinflammatory and by immune suppression.[1]

Hydrocortisone was discovered in 1955.[5] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[6] It is available as a generic medication.[1] The wholesale cost in the developing world is about 0.27 USD per day as of 2014 for the form taken by mouth.[7] In the United States it costs less than 25 USD for a typical month of treatment.[3]


 







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